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📰 "Cross-species comparative connectomics reveals the evolution of an olfactory circuit"
biorxiv.org/content/10.1101/20
#Neuroscience
#Connectomics
#Evolution
#Drosophila #Behaviour #Larva

bioRxiv · Cross-species comparative connectomics reveals the evolution of an olfactory circuitAnimal behavioural diversity ultimately stems from variation in neural circuitry, yet how central neural circuits evolve remains poorly understood. Studies of neural circuit evolution often focus on a few elements within a network. However, addressing fundamental questions in evolutionary neuroscience, such as whether some elements are more evolvable than others, requires a more global and unbiased approach. Here, we used synapse-level comparative connectomics to examine how an entire olfactory circuit evolves. We compared the full antennal lobe connectome of the larvae of two closely related Drosophila species, D. melanogaster and D. erecta, which differ in their ecological niches and odour-driven behaviours. We found that evolutionary change is unevenly distributed across the network. Some features, including neuron types, neuron numbers and interneuron-to-interneuron connectivity, are highly conserved. These conserved elements delineate a core circuit blueprint presumably required for fundamental olfactory processing. Superimposed on this scaffold, we find rewiring changes that mirror each species ecologies, including a systematic shift in the excitation-to-inhibition balance in the feedforward pathways. We further show that some neurons have changed more than others, and that even within individual neurons some synaptic elements remain conserved while others display major species-specific changes, suggesting evolutionary hot-spots within the circuit. Our findings reveal constrained and adaptable elements within olfactory networks, and establish a framework for identifying general principles in the evolution of neural circuits underlying behaviour. ### Competing Interest Statement C.S.X is the inventor of a US patent assigned to HHMI for the enhanced FIB-SEM systems used in this work: Xu, C.S., Hayworth K.J., Hess H.F. (2020) Enhanced FIB-SEM systems for large-volume 3D imaging. US Patent 10,600,615, 24 Mar 2020. European Molecular Biology Organization, ALTF1114-2024 International Human Frontier Science Program Organization, LT0036/2025-L, RGY0052/2022 European Research Council, 802531 Paul G. Allen Family Foundation Vallee Foundation, https://ror.org/05nmp3276 Chan Zuckerberg Initiative (United States), https://ror.org/02qenvm24, CP-2-1-Prieto-Godino The Francis Crick Institute, https://ror.org/04tnbqb63, CC2067, CC2240

From Silke Sachse:

"I would like to draw your attention to the announcement of a professorship (W3 level) in Behavioral Physiology at the University of Würzburg. Please help to spread the word to suitable candidates."

Application deadline is June 22nd, 2025.

Details can be found here:

German: biologie.uni-wuerzburg.de/file

English: biologie.uni-wuerzburg.de/file

"“For me, the takeaway is we know very little—even the very basic of how they find a site,” Parzer says. “Then there’s a lot of species variation. Why are some puddling a lot? Why are some not at all? We have some species where females also puddle—why is that? And then we noticed there’s a big gap. A whole continent is essentially missing—Africa—so there clearly needs to be something done in that area as well.”"

entomologytoday.org/2025/05/13

Entomology Today · To Puddle or Not To Puddle: Review Highlights Unanswered Questions About Butterfly BehaviorA new review on "puddling" in butterflies details current knowledge on this nutrient-gathering behavior and how much remains unknown about why they gather.

#Anthropocentrism and human #hubris:

🚾 Yeah, humans invented #toiletPaper in the 2nd century in China and fabricate it in the Western world since the 19th c! Before/elsewhere, they used shitsticks, clay shards, stones, sometimes even water. Animals would never do this!

Wait.

🐵 Chimpanzees would never scratch their skin with broken shards - they use leaves after having a poo. And make their own medicine from plants. theguardian.com/environment/20

The Guardian · Chimpanzees use leaves to wipe bums and clean up after sex, study findsVon Nicola Davis
#health#hygiene#healing
Fortgeführter Thread

Day 32 cont 🗳️⚔️🤜🤛👊

As the election gets closer, #extremism and #conflict is happening at polling booths with unruly candidate, party members and constituants.

“A barrage of #complaints about #threatening and #aggressive #behaviour at polling booths has fuelled tension in Australia’s most hotly #contested #electorates and prompted the #ElectoralCommission to warn #candidates in marginal seats that such behaviour would discourage #voters

#AusPol <archive.md/5KgGv> / <smh.com.au/politics/federal/th> (paywall)