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#optogenetics

1 Beitrag1 Beteiligte*r0 Beiträge heute
Virgile Andreani ⏚ 🇵🇸

My previous lab, at Boston University, is searching for a new postdoc! Besides being an excellent and rigorous scientist, Mary Dunlop has an entirely deserved reputation of being an exceptional group leader. My three years in her lab have been the highlight of my scientific career so far, and if I am leading a research team one day, I will already be happy if I can make it half as kind, thoughtful and supportive as she made her group. I'd be delighted to answer any questions that potential candidates may have. Announcement below:

> My lab is hiring! We’re looking for a postdoctoral scholar in the area of optogenetic control, single-cell analysis, and gene expression dynamics in microbial systems. For more details see dunloplab.com/

Dunlop LabDunlop Lab
#SystemsBiology#SyntheticBiology#GeneExpression
Victoria Stuart 🇨🇦 🏳️‍⚧️

Very cool 😀

Discovering neural policies to drive behaviour by integrating deep reinforcement learning agents with biological neural networks
nature.com/articles/s42256-024
klab.tch.harvard.edu/publicati
news.ycombinator.com/item?id=4

* hybrid system trained on target-finding task
* worm nervous system, deep RL agent interfaced via optogenetics
* neural circuits produce goal-directed behavior

NatureDiscovering neural policies to drive behaviour by integrating deep reinforcement learning agents with biological neural networks - Nature Machine IntelligenceDeep reinforcement learning (RL) has been successful in many fields but has not been used to directly improve behaviours by interfacing with living nervous systems. Li et al. present a framework that integrates deep RL agents with the nervous system of the nematode Caenorhabditis elegans. Their study shows that trained agents can assist animals in biologically relevant tasks and can be studied after training to map out effective neural policies.
#optogenetics#ReinforcementLearning#SyntheticBiology
Thiago Carvalho

'The Vilcek Foundation launches the fourth chapter in our series of manga produced in collaboration with Hiroki Otsuka. The manga celebrate our Vilcek Foundation prizewinners, and this latest manga highlights the work of neuroscientist and 2020 Vilcek Creative Promise Prizewinner Viviana Gradinaru.'
#neuroscience #Optogenetics

vilcek.org/news/visualizing-op

Vilcek FoundationVisualizing optogenetics: New manga celebrates neuroscientist Viviana Gradinaru - Vilcek FoundationThe fourth in our series of manga celebrating our immigrant prizewinners shines a spotlight on neuroscientist Viviana Gradinaru.
Moritz Negwer

Cool finding: In this #neuroscience paper, they identify a neuronal *in*activity marker. They do so with a cell-culture #optogenetics screen, then validate it all the way to whole mouse brains, co-staining with an activity marker (c-Fos in this case). Makes sense as well, the marker is part of the cell's energy metabolism. This is going to be super useful.

Phosphorylation of pyruvate dehydrogenase inversely associates with neuronal activity
Yang et al., Neuron 2024
cell.com/neuron/fulltext/S0896

Antwortete im Thread
*
Teixi

@kordinglab

Learnead the #scihistory of #optogenetics becoming new neuro tech tool, from this masterful lecture by Peter Hegemann

In which mentions precedents —we discovered, not new at all 1866 A S Faminzin. 1984 chemist K Nakanishi, physicist K Foster. Discouraged except for Ursula Goodenough in the audience— professorship skills!
~ 16:40
youtube.com/watch?v=hOKLMjuwlL

ps: albeit after his lecture watched somehow disappointed the overpromise by the following lecturers, yet that's another thing ;)

YouTubeOptogenetics: Illuminating the Path toward Causal NeuroscienceVon Harvard Medical School
eLife

Optogenetics helped researchers study the role of the microtubule end-binding protein, EB1, in the growth of neurons. Here, the end of a neuron reaches a strip of blue light which optogenetically inactivates EB1 causing the microtubule fibres that usually push and grow the cell to fall apart. #Neuroscience #Optogenetics #Microtubules #12DaysOfeLife elifesciences.org/articles/841

Albert Cardona

This Scientific American issue from 1979 reads like a who's who of early neuroscience research:

Cowan, Crick, Kandel, Hubel, Wiesel, Stevens ...

scientificamerican.com/issue/s

#icanhazpdf ?

In particular, Ordaz et al. 2017 doi.org/10.4103%2F1673-5374.21 credit Francis Crick in this issue as having formulated the need for optical methods with cellular resolution to control the activity of neurons - a precursor to the development of optogenetics.

Crick's idea didn't come out of the blue: by then, bacteriorhodopsins (light-gated ion channels for protons) had been known and published for almost a decade (Oesterhelt and Stoeckenius, 1971 nature.com/articles/newbio2331 ), and halorhodopsin (light-gated chloride channel) had been reported 2 years earlier (Matsuno-Yagi and Mukohata 1977 sciencedirect.com/science/arti ).

(Channelrhodopsin, a light-gated cation channel that can depolarise and therefore activate neurons, wasn't reported until 2002, by Nagel et al. 2002 science.org/doi/full/10.1126/s ).

Scientific AmericanScientific American Magazine Vol. 241 No. 3 | Scientific AmericanScientific American is the essential guide to the most awe-inspiring advances in science and technology, explaining how they change our understanding of the world and shape our lives.
#neuroscience#optogenetics
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