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#neurology

14 Beiträge11 Beteiligte0 Beiträge heute

Fun fact-

Your brain isn't a single consciousness.

It's more like a group of bickering smaller consciousness trying to make sense of all the information independently, then your perception of reality is the general sum of all that information.

The left and right half are essentially two different people by themselves.

Then they have their own counsel too.

You're like seven souls all trapped in one consciousness.

#writing#biology#neurology

Oh, the things "not quite right," each of us have to contend with - stuff that may exist in both the mental & physical planes, 1 or the other - frighteningly real to us, but other than how we react if they happen in the presence of others (who have 0 clue), and the descriptions we try to give to doctors, there's just "nothing we can do," or, at least, that's the response we often get.

Like the LOUD CLANGING sound I just experienced in a dead quiet room. Made me jump. All in my head. #neurology

'Perihaematomal Oedema Evolution over 2 Weeks after Spontaneous Intracerebral Haemorrhage and Association with Outcome: A Prospective Cohort Study' - a #Research article in the Karger: #Neurology and #Neuroscience collection on #ScienceOpen:

🔗 scienceopen.com/document?vid=b

ScienceOpenPerihaematomal Oedema Evolution over 2 Weeks after Spontaneous Intracerebral Haemorrhage and Association with Outcome: A Prospective Cohort Study<p xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" dir="auto" id="d36007e318"> <b> <i>Introduction:</i> </b> We know little about the evolution of perihaematomal oedema (PHO) >24 h after ICH onset. We aimed to determine the trajectory of PHO after ICH onset and its association with outcome. <b> <i>Methods:</i> </b> We did a prospective cohort study using a pre-specified scanning protocol in adults with first-ever spontaneous ICH and measured absolute PHO volumes on CT head scans at ICH diagnosis and 3 ± 2, 7 ± 2, and 14 ± 2 days after ICH onset. We used the largest ICH if ICHs were multiple. The primary outcomes were (a) the trajectory of PHO after ICH onset and (b) the association between PHO (absolute volume at the time when most repeat CT head scans were obtained, and change in PHO volume at this time compared with the first CT head scan) and poor functional outcome (modified Rankin scale 3–6 at 90 days). We pre-specified multivariable logistic regression models of this association adjusting analyses for potential confounders: age, GCS, infratentorial ICH location, and intraventricular extension. <b> <i>Results:</i> </b> In 106 participants of whom 49 (46%) were female, with a median ICH volume 7 mL (interquartile range [IQR] 2–22 mL), the trajectory of median PHO volume increased from 14 mL (IQR: 7–26 mL) at diagnosis to 18 mL (IQR: 8–40 mL) at 3 ± 2 days ( <i>n</i> = 87), 20 mL (IQR: 8–48 mL) at 7 ± 2 days ( <i>n</i> = 93) and 21 mL (IQR: 10–54 mL) at 14 ± 2 days ( <i>n</i> = 78) ( <i>p</i> = <0.001). PHO volume <i>at</i> each time point was collinear with ICH volume at diagnosis (│r│ >0.7), but the change in PHO volume between diagnosis and each time point was not. Given collinearity, we used total lesion (i.e., ICH + PHO) volume instead of PHO volume in a logistic regression model of its association <i>at</i> each time point with outcome. Increasing total lesion (ICH + PHO) volume at day 7 ± 2 was associated with poor functional outcome (adjusted OR per mL 1.02, 95% CI: 1.00–1.03; <i>p</i> = 0.036), but the increase in PHO volume between diagnosis and day 7 ± 2 was not associated with poor functional outcome (adjusted OR per mL 1.03, 95% CI: 0.99–1.07; <i>p</i> = 0.132). <b> <i>Conclusion:</i> </b> PHO volume increases throughout the first 2 weeks after onset of mild to moderate ICH. Total lesion (ICH + PHO) volume at day 7 ± 2 was associated with poor functional outcome, but the change in PHO volume between diagnosis and day 7 ± 2 was not. Prospective cohort studies with larger sample sizes are needed to investigate these associations and their modifiers. </p>