Get to know Hristo Svilenov, our newly appointed Professor of #BiopharmaceuticalTechnology, in the latest "NewIn" episode. He is exploring the pharmaceutical potential of #proteins produced in #livingcells: http://go.tum.de/347804

Get to know Hristo Svilenov, our newly appointed Professor of #BiopharmaceuticalTechnology, in the latest "NewIn" episode. He is exploring the pharmaceutical potential of #proteins produced in #livingcells: http://go.tum.de/347804
Researchers study extinct hominins using enamel proteins from their teeth https://arstechni.ca/mDex #ancientproteins #humanevolution #paleontology #evolution #massspec #proteins #Science #Biology
ERCnet by Forsythe et al. improves the prediction of protein interactions using evolutionary rate covariation, overcoming challenges like gene duplication and other sources of phylogenetic noise.
doi.org/10.1093/molbev/msaf089
I have a new favorite lunchtime treat. High-quality protein, highly bioavailable, and digestible. A meal suitable for people with autoimmune disorders.
Hard-boiled eggs with tuna. It can be fresh or canned. I season it with olive oil, turmeric, ginger, black pepper, and salt. But that's up to you.
In autoimmune diseases, slightly more protein than normal is needed due to the constant destruction and renewal of tissues and blood caused by the outbreaks of antibody attacks.
But since most patients with autoimmune disorders also have intestinal inflammation, it is better to ingest proteins with less complex molecular structures and with less toxicity load. Simply put, the smaller the creature, the more digestible its protein. So, according to this criterion, eggs are best, followed by fish, birds, and finally four-legged mammals.
Obviously, depending on your tolerance and digestive capacity, you choose what to eat.
The important thing is not to eat for pleasure or ideology, but according to the needs of the body.
And if you don't have any health problems, tuna with eggs is still a delicacy.
#autoimmunedisease #proteins #eggs #tuna #EatHealthy #actuallyautistic
#GenerativeAI tool marks a milestone in #biology
Trained on a dataset of 100,000 organisms from #bacteria to #humans – and a few extinct ones – #Evo2 can predict the form and function of #proteins in the #DNA of all domains of life and run experiments in a fraction of the time it would take a traditional lab.The system can quickly determine what #gene mutations contribute to certain #diseases and what mutations are mostly harmless.
https://news.stanford.edu/stories/2025/02/generative-ai-tool-marks-a-milestone-in-biology-and-accelerates-the-future-of-life-sciences
#genetics
Researchers developed synthetic mini-#proteins that inhibit both #amyloid formation in #Parkinsons and harmful protein interactions between #Alzheimers, Parkinsons and #type2diabetes in experimental models: http://go.tum.de/819859
A.Eckert
#EukaryoticCells emerged as #evolutionary algorithmic phase transition: #Eukaryogenesis happened abruptly, led by the tension of increasing gene length and the constraints on producing longer #proteins // #EvolutionaryBiology #ComputerBiology #evolution
The eukaryotic cell emerged as an evolutionary algorithmic phase transition / Eukaryogenesis happened abruptly, led by the tension of increasing gene length and the constraints on producing longer proteins / Evolvement of the eukaryotic cell is the most significant increase in complexity in the history of life's evolution on Earth https://press.uni-mainz.de/eukaryotic-cell-emerged-as-evolutionary-algorithmic-phase-transition/
For these reasons I am glad to live here and not there.
Jumbo eggs (between 75 and 80 grams) cost between 8,000 and 9,000 pesos (7-8 dollars) for 30 units (They last me approximately 4-5 days)
They raised prices three times in one month, due to the impact of influenza A.
They are the main animal protein that I eat.
Where do #proteins go in cells? Next-generation methods map the molecules’ hidden lives! Spatial #proteomics at the lab of Matthias Mann at Max Planck Institute for Biochemistry is helping biologists to uncover how cells work by mapping where proteins operate.
What determines the folding and stability of protein structures? In his fourth lecture, Dr. Ali Hassanali from the Abdus Salam International Centre for Theoretical Physics (ICTP) explores the intricate world of protein secondary structures, focusing specifically on alpha helices and beta sheets. Dr. Hassanali explains how these structures are stabilized through a variety of interactions, including hydrogen bonding and electrostatic effects, and the critical role of dihedral angles as illustrated by the Ramachandran plot.
This lecture also highlights the essential contributions of cysteine in forming disulfide bonds, which enhance protein stability in challenging environments. By examining the interplay of molecular interactions, Dr. Hassanali provides insights into the architectural and functional significance of these secondary structures as well as their evolutionary adaptations.
Join us for this #OpenAccess lecture and engage in discussions with Dr. Hassanali himself and other members of the Enabla community: https://enabla.com/pub/606/about
**Biological Constraint Engine**
Validates generated sequences against biological feasibility rules
Predicts #protein folding, metabolic interactions, and cellular dynamics
(Again this is something #AI is already good at)
Ensures synthetic organisms would be thermodynamically viable
**Simulation Environment**
Virtual cell environment to test synthetic genomes before physical synthesis.
(We have done this a while ago - pre AI)
Models interactions between #genes, #proteins, and environment
5/6
“I think it will be a gamechanger very broadly, not just for people in my field,” said senior study author James Liu, a group leader at Howard Hughes Medical Institute's Janelia Research Campus. “It was a tool developed to answer a very obscure question, but I think all biologists can use the technique in their favorite samples.”
#research #science #biotechnology #technology #RNA #proteins
Protein design: Flexible components allow new architectures
https://phys.org/news/2025-02-protein-flexible-components-architectures.html
"Pac-Man with a ponytail" #proteins, as #GRK proteins are nicknamed, regulate everything from night vision to heartbeats. A structural biology scholar explains how studying their structure could enhance a range of drugs. https://theconversation.com/pac-man-with-a-ponytail-proteins-regulate-everything-from-night-vision-to-heartbeats-studying-what-grks-look-like-could-improve-an-array-of-drugs-248298
Priyanka Naik, Purdue University
6 Sources of Protein That Aren’t Meat https://www.diningandcooking.com/1937138/6-sources-of-protein-that-arent-meat/ #antioxidants #beans #ContentType:Service #CookingAndCookbooks #DietAndNutrition #Fiber(Dietary) #nutrition #nuts #proteins #Research #Vegetables #vegetarianism
Scientists developed a method for purifying #proteins from cell extracts or cultures using short-wave #UVlight, which is invisible to humans. The technique is more efficient and gentler than previous methods: http://go.tum.de/385699
#BiologicalChemistry #chromatography
S.Bauer
Scientists Describe Rare Syndrome Following Covid Vaccinations https://www.byteseu.com/766998/ #Blood #DiseaseRates #ImmuneSystem #LongCovid #Proteins #Research #Science #Tinnitus #VaccinationAndImmunization #YourFeedScience
Genetically engineered #potatoes can produce cow milk #proteins to reduce the need for #cows & thus reduce GHG emissions, as the #dairy industry is an important driver of such #emissions, producing as much as the aviation & shipping industries combined... (1/2) https://www.zmescience.com/science/news-science/protein-dairy-inside-potato/ #GMO