Frühere Suchanfragen

Keine früheren Suchanfragen

Suchoptionen

Nur verfügbar, wenn angemeldet.
mastodontech.de ist einer von vielen unabhängigen Mastodon-Servern, mit dem du dich im Fediverse beteiligen kannst.
Offen für alle (über 16) und bereitgestellt von Markus'Blog

Verwaltet von:

Serverstatistik:

1,5 Tsd.
aktive Profile

mastodontech.de: ÜberStatusProfilverzeichnisDatenschutzerklärung

Mastodon: ÜberApp herunterladenTastenkombinationenQuellcode anzeigenv4.4.0-beta.2

#general

26 Beiträge18 Beteiligte3 Beiträge heute
abo

Report MLOL 2024: un commento
Lo scorso marzo MLOL ha pubblicato il Report Dati e tendenze della lettura digitale in biblioteca (titolo piuttosto provocatorio, trattandosi di una piattaforma di prestito digitale) a firma dell’AD di Horizons Unlimited Giulio Blasi. Poche paginette arricchite da molte tabelle e un lungo elenco di ben 908 case editrici distribuite in piattaforma. Una lettura in ogni caso
bibliotecaria.noblogs.org/repo
#General #mlol #report

bibliotecaria.noblogs.orgReport MLOL 2024: un commento – BibliotecAria
US

europesays.com/us/2309/ Unraveling time-dependent genetic components underlying alcohol response #BehavioralSciences #BehaviouralGenetics #BiologicalPsychology #general #GeneticMarkers #Genetics #Medicine/PublicHealth #Neurosciences #Pharmacotherapy #psychiatry #Science #UnitedStates #UnitedStates #US

Unraveling time-dependent genetic components underlying alcohol response
United States · Unraveling time-dependent genetic components underlying alcohol response - United StatesWhile numerous studies have examined the subjective response to alcohol as an intermediate phenotype to understand its variability, heritability, and predictive capacity for alcohol-related disorders, in-depth analyses linking alcohol reactivity indicators to genetic factors within a large cohort have been absent. Our study aimed to quantify the exact contribution of each genetic variant relevant to the alcohol metabolism to the variability in alcohol response. Specifically, we focused on two primary genes involved in alcohol metabolism (ALDH2 and ADH1B) and three additional loci (ALDH1B1, ALDH1A1, and GCKR) that have been shown to have significant associations with drinking behaviors in Japanese individuals. We conducted the first study to assess the relationship between subjective response to alcohol (SR), evaluated by various assessment subscales, and genetic factors using an intravenous clamp technique in 429 healthy Japanese young adults. By reducing the dimensionality of the data to assess similarity structures, we identified three distinct clusters of SRs and participants. Each participant cluster exhibited a distinct alcohol response profile shaped by specific genetic contributions. Participant cluster 1 demonstrated the strongest response, followed by participant cluster 2, and then participant cluster 3. Participant cluster 1 may also be the most strongly influenced by the allelic status of ALDH2 and ADH1B. SR patterns varied accordingly, and the enrichment of the ALDH2*2 and ADH1B*2, differed across both participant and subscale clusters. Notably, the three participant clusters closely aligned with the three subscale clusters, highlighting a consistent genotype–phenotype relationship. Furthermore, the proportion of variance explained by these genes also varied across subscale clusters. Contrary to known functions, ADH1B showed associations at later timings when ALDH2 associations attenuate. Our three-cluster classification may improve prevention by enabling early identification of individuals at health risk.
AngesagtLive-Feeds
Über